SETX sumoylation

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SETX sumoylation

Senataxin (SETX) is a putative RNA:DNA helicase that is mutated in two distinct juvenile neurological disorders, AOA2 and ALS4. SETX is involved in the response to oxidative stress and is suggested to resolve R loops formed at transcription termination sites or at sites of collisions between the transcription and replication machineries. R loops are hybrids between RNA and DNA that are believed...

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Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation

Constitutive and induced protein SUMOylation is involved in the regulation of a variety of cellular processes, such as regulation of gene expression and protein transport, and proceeds mainly in the nucleus of the cell. So far, several hundred SUMOylation targets have been identified, but presumably they represent only a part of the total of proteins which are regulated by SUMOylation. Here, we...

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Pc2 and SUMOylation.

Polycomb proteins are key regulators of transcription in metazoan organisms. Recent work has shed light on the nature of the polycomb protein complexes in flies and mammalian cells. Multiple enzymatic activities have been shown to associate with polycomb complexes, including histone methyltransferase, histone deacetylase and ubiquitination activities, which are primarily directed towards the mo...

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Predicting SUMOylation Sites

Recent evidence suggests that SUMOylation of proteins plays a key regulatory role in the assembly and dis-assembly of nuclear subcompartments, and may repress transcription by modifying chromatin. Determining whether a protein contains a SUMOylation site or not thus provides essential clues about a substrate’s intra-nuclear spatial association and function. Previous SUMOylation predictors are l...

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SUMOylation of nuclear actin

Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport. Nevertheless, the regulation of nuclear actin by posttranslational modifications has not been investigated. We now show that nuclear actin is modified by SUMO2 and SUMO3 and that computa...

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ژورنال

عنوان ژورنال: Rare Diseases

سال: 2014

ISSN: 2167-5511

DOI: 10.4161/rdis.27744